GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
نویسندگان
چکیده
منابع مشابه
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor internalization into endosomes. However, it has been demonstrated that some GPCRs activate G proteins from within internalized cellular compartments, resulting in sustained signaling. We have used a variety of biochemi...
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متن کاملCompeting G protein-coupled receptor kinases balance G protein and b-arrestin signaling
1 BIOS Group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements, Nouzilly, France, 2 CNRS, UMR7247, Nouzilly, France, 3 Université François Rabelais, Tours, France, 4 IFCE, Nouzilly, France, 5 Contraintes Team, INRIA Paris-Rocquencourt, Le Chesnay, France, 6 Department of Medicine, Duke University Medical Center, Howard Hughes Medical Institute, Durham, NC, USA, 7 Sisyphe T...
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ژورنال
عنوان ژورنال: Cell
سال: 2016
ISSN: 0092-8674
DOI: 10.1016/j.cell.2016.07.004